Contraindicated (1)pentobarbital will lessen the extent or influence of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Lively metabolites.
pentobarbital will reduce the level or effect of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
Reserve concomitant prescribing of these drugs in clients for whom other treatment method choices are inadequate. Limit dosages and durations on the least required. Keep an eye on carefully for indications of respiratory depression and sedation.
pentobarbital will decrease the level or effect of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
CYP3A4 inducers may possibly boost the development of your neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Carefully keep an eye on sufferers taking ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.
Insignificant (1)pentobarbital will decrease the extent or outcome of paclitaxel protein sure by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.
The efficacy of hormonal contraceptives may very well be lowered. Use another technique of contraception or simply a backup system when enzyme inducers are utilized with combined hormonal contraceptives (CHCs), and carry on backup contraception for 28 days right after discontinuing enzyme inducer to ensure contraceptive trustworthiness.
buprenorphine, prolonged-acting injection and pentobarbital equally enhance sedation. Steer clear of or Use Alternate Drug. Limit use to clients for whom choice therapy options are inadequate
pentobarbital will minimize the extent or impact of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Mysterious.
Observe Intently (1)pentobarbital will reduce the level or outcome of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Caution when discontinuing CYP3A4 inducers that happen to be coadministered with hydrocodone; plasma concentrations of hydrocodone may possibly maximize and may result in potentially lethal respiratory depressionSerious - Use Substitute (1)hydrocodone, pentobarbital.
pentobarbital will minimize the extent or outcome of eucalyptus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
pentobarbital will decrease the extent or influence of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will lower the get more info level or impact of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.